CALL FOR PAPERS Cardiovascular and Cerebrovascular Aging—New Mechanisms and Insights And the beat goes on: maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat
نویسندگان
چکیده
Kelly M. Grimes,* Anilkumar K. Reddy,* Merry L. Lindsey, and Rochelle Buffenstein Department of Physiology and the Sam and Ann Barshop Institute for Aging and Longevity Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas; Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, Texas; Indus Instruments, Webster, Texas; Mississippi Center for Heart Research, Department of Physiology and Biophysics, University of Mississippi Medical Center and Research Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, Mississippi
منابع مشابه
CALL FOR PAPERS Cardiovascular Aging Vascular aging in the longest-living rodent, the naked mole rat
Csiszar A, Labinskyy N, Orosz Z, Xiangmin Z, Buffenstein R, Ungvari Z. Vascular aging in the longest-living rodent, the naked mole rat. Am J Physiol Heart Circ Physiol 293: H919–H927, 2007. First published April 27, 2007; doi:10.1152/ajpheart.01287.2006.— The naked mole rat (NMR; Heterocephalus glaber) is the longestliving rodent known [maximum lifespan potential (MLSP): 28 yr] and is a unique ...
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Cardiovascular disease is a main cause of morbidity and a leading cause of death of elderly Americans. Studies identifying the pathophysiological mechanisms underlying cardiovascular aging hold promise to develop treatments to delay/prevent coronary artery disease and stroke in the elderly. Evidence supporting the roles of oxidative stress and inflammation in the cardiovascular aging process is...
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The naked mole-rat (NMR) Heterocephalus glaber is an exceptionally long-lived rodent, living up to 32 years in captivity. This extended lifespan is accompanied by a phenotype of negligible senescence, a phenomenon of very slow changes in the expected physiological characteristics with age. One of the many consequences of normal aging in mammals is the devastating and progressive loss of skeleta...
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BACKGROUND Studies comparing similar-sized species with disparate longevity may elucidate novel mechanisms that abrogate aging and prolong good health. We focus on the longest living rodent, the naked mole-rat. This mouse-sized mammal lives ~8 times longer than do mice and, despite high levels of oxidative damage evident at a young age, it is not only very resistant to spontaneous neoplasia but...
متن کاملGenome Stability Maintenance in Naked Mole-Rat
The naked mole-rat (Heterocephalus glaber) is one of the most promising models used to study genome maintenance systems, including the effective repair of damage to DNA. The naked mole-rat is the longest lived rodent species, which is extraordinarily resistant to cancer and has a number of other unique phenotypic traits. For at least 80% of its lifespan, this animal shows no signs of aging or a...
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تاریخ انتشار 2014